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KMID : 0604520070330040219
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 4 p.219 ~ p.225
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Cosmetic Application of Bis-ethylhexyloxyphenolmethoxyphenyltriazine (BEMT) Loaded Solid Lipid Nano-particle (SLN)
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Lee Geun-Soo
Lee Dong-Hwan
Pyo Hyeong-Bae
Choi Tae-Boo
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Abstract
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Bis-ethylhexyloxyphenolmethoxyphenyltrizine (BEMT) is one of the most widely used chemical UVA+UVB double absorbers in sunscreen products. But topical application of BEMT is restricted due to its defects in product. The purpose of this study is to adopt the sunscreen product of solid lipid nano-particles containing BEMT (BEMT-SLN). The particle diameters, the encapsulation efficiencies and the crystallization index (C.I.) are about 330nm, 93.3 % and the 4.3 %. As a result, in vitro penetration and release of BEMT were generally higher in O/W emulsion than the SLN formulation. However in vivo study, it was shown that the rate of release could be decreased by 80 % in the SLN formulation. The sun protection factor (SPF) of the SLN formulation increased by 100 % in the in vitro UV protection test. Therefore, SLN formulation potentiated the UV-blocking power of BEMT. This study suggest that SLN can be used for the encapsulation of BEMT.
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KEYWORD
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SLN, Bis-ethylhexyloxyphenolmethoxyphenyltrizine, penetration, release, UV-blocking
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